PAIN Research Laboratory
In studies of neurophysiology of chronic pain (e.g. chemogenic low back pain and CRPS), behavioral measurements of cutaneous hyperalgesia and allodynia were correlated with extracellular and intracellular recordings of sensory neurons with chronic compression injury of the DRG or the peripheral nerve. Our first goal is to study the etiology of low back pain originated in the intact or injured lumbar ganglia, and to determine the role of inflammatory cytokines in the development of pain and hyperalgesia after injury of the ganglion or damage to the peripheral nerve. Our second goal is to study the activity-dependent sympathetic sprouting as a cause of CRPS.
Dobretsov, Maxim, Ph.D.
Munir, M.A., Jaffar, M., Arshad, M., Akhter, M.S. and Zhang, J.-M. Reduced duration of muscle relaxation with rocuronium in a normocalcemic hyperparathyroid patient. Canadian Journal of Anesthesia, 50: 558-561, 2003.
Dobretsov, M., Hastings, S.L., Romanovsky, D., Stimers, J.R. and Zhang, J.-M. Mechanical hyperalgesia in rats with systemic or local hyperglycemia. Brain Research, 960 (1-2), 167-176, 2003.
Li, H., Liu, B.-G., Dobretsov, M. Brull, S.J. and Zhang, J.-M., Thermosensitivity of large primary sensory neurons. Brain Res, 926(1-2):18-26, 2002.
Dobretsov, M, Hasting, S.L., Stimers, J.R. and Zhang, J.-M. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of Neuroscience Methods, 110: 9-15, 2001.