The UAMS Department of Anesthesiology has both investigator-initiated and industry sponsored projects. These are divided between basic and clinical research activities, and are funded by the department, industry and the NIH.

Numerous opportunities exist for research participation. Residents can participate in the development of case reports/series, industry-sponsored drug and device studies, and NIH-funded basic and clinical research.
Areas of research expertise in the department include educational and quality assurance research, pain management studies, and experimental therapeutics. In addition, the department has collaborations with numerous colleges and departments on campus, which can provide other opportunities.

Summary of Research Activities

Funded Research


Title of Grant

Agency and Acct #


Napolitano CA (PI)

Incidence of Perioperative Ventricular Tachydysrhythmias In Cardiopulmonary Bypass Patients

Ischemic Research & Education Fnd

Zabala LM (PI)Schmitz ML, Jaquiss RDB, Imamura M, Martin TW, Bhutta A, Hussain S

A Phase II Multicenter, Randomized, Double-Blind, Parallel Group, Dose-Ranging, Effect-Controlled Study to Determine the Pharmacokinetics and Pharmacodynamics of Sodium Nitroprusside in Pediatric Subjects


11/06 - present

Interdisciplinary Research

Name of Project/Grant

Faculty Involved


Length of Project

Serum Natriuretic Peptide Assays in Children with Dilated Cardiomyopathy: Correlation of serum levels to echocardiographic functional parameters and Clinical symptoms.

Dyamenahalli U, Morrow WR, Frazier EA, Apuya J, and Kajevska IH


Expression and function of Na+,K+-ATPase in rat calx synapse

Dobretsov M, Von Gersdorff, H

UAMS, Oregon Health Sci U

Expression of beta 3 subunit of Na+,K+-ATPase and pain in mice

Dobretsov M, Mogil J, Clark D

UAMS, Pain Genetics Lab, Canada, Stanford

Ketamine Pharmacokinetics in Children Undergoing Cardiac Surger

Bhutta A (PI); Stowe C, Schmitz ML, Zabala L, Ullah S, Jaquiss RDB, Imamura M, James L, Watkins WB


02/07 - present

Pediatric Mobile Cardiac ECMO: A Single Institution Experience

Cabrera A (PI)  Schmitz ML, Fiser R, Imamura M, Jaquiss RDB, Fiser WP


04/06 - present

Thromboelastogam Blood Analysis of Pediatric Cardiac Surgery Patients

Schmitz ML (PI) Fiser WP, Zabala LM


04/07 - present

Internet Use by Parents Regarding Their Child¹s Surgical Procedure at Arkansas Children¹s Hospital

Schmitz ML (PI) Pierce CD; Martin TW, Killebrew PM, Simpson PM, Zabala LM


02/07 - present

Obesity Incidence in Children with Congenital Heart Disease

Ray T (PI) Jaquiss RDB, Imamura M, Schmitz ML, Best T.


02/06 - present

Diagnosis of Hemangiomas and Vascular Malformations Using Non-Invasive Imaging Devices

Stack B (PI), Kokoska M, Shafirstein G, Suen J, Buckmiller L, James CJ, Nicholas R, Schmitz ML, Vural EA.


01/06 - present

Entropy and Fractal Pattern of Near Infrared Spectoscopy Measurements in Children with Heart Disease

Bhutta A (PI),Tuzcu V, Nas S, Prodham P, Ullah S, Watkins WB, Zabala LM, Schmitz ML, Imamura M, Jaquiss RDB, Dyamenahalli U


06/06 - present

Lactate Levels in Children with Atrial Septal Defects Undergoing Surgical Repair

Prodham P (PI); Jaquiss RDB, Bhutta A, Dyamenahalli U, Schmitz ML


05/06 - present

Ultrasonography of Neonatal Blood Vessels: Implications for Vascular Access

Prodhan P (PI); Dyamenahalli U, Schmitz ML, Zabala L, Lyle R, Ullah S


02/06- present

Use of Ketamine Prior to Cardiopulmonary Bypass in Children

Bhutta A (PI), Fontenot E, Drummond-Webb JJ, Schmitz ML, Anand KS, Kajevska I, James LG, Simpson PM, Ward-Begnoche W


04/04 - present

A Three Year Retrospective Review of the Use of Aprotinin to Reduce Blood Loss During Idiopathic Scoliosis Surgery at Arkansas Children’s Hospital

Al-Takrouri H (PI), Martin TW, Siddiqui S, Schmitz ML, McCarthy R, Simpson P


06/06 - present

A Multicenter, Inpatient, Open-Label, within Subject Dose Titration Study to Characterize the Pharmacokinetics/Pharmacodynamics, Safety and Efficacy of Hydromorphone HCl Oral Solution in Subjects from 28 Days to 16 Years of Age, Inclusive, Who Require Opioid Analgesics for Postoperative Pain

Schmitz ML (PI),Sangari TS, Bhutta A, Zabala LM, Guatam NK, Siddiqui MS, Killebrew PM, Pierce CD

ACH and Purdue Pharma L.P

04/07 - present